Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TYMP | P19971 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093922 | 0.85 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10PTGS2 | |
| SCHEMBL1572915 | 0.85 | ALDH1A1 (0.68) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL1573105 | 0.83 | KDM4E (0.55) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL8441892 | 0.80 | KDM4E (0.52) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL1573566 | 0.80 | TYMP (0.62) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL1573392 | 0.80 | TYMP (0.62) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL1573106 | 0.79 | PTGS2 (0.50) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL3786153 | 0.78 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL29639239 | 0.77 | PTGS2 (0.59) | KDM4EALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL7095155 | 0.76 | TYMP (0.53) | KDM4EPLA2G10ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | claimed |
| EP-1542978-B1 | NOVEL BIO-ACTIVE MOLECULES | ORCHID RES LAB LTD (IN) | 2011-04-13 | — | — | EP | disclosed |
| US-7317014-B2 | Bio-active pyrimidine molecules | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2008-01-08 | — | — | US | disclosed |
| EP-1542978-A1 | NOVEL BIO-ACTIVE MOLECULES | Orchid Chemicals and Pharmaceuticals Ltd (IN) | 2005-06-22 | — | — | EP | disclosed |
| US-20050107413-A1 | Novel bio-active molecules | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2005-05-19 | — | — | US | disclosed |
| WO-2004009560-A1 | NOVEL BIO-ACTIVE MOLECULES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2004-01-29 | — | — | WO | disclosed |
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107413-A1 | Novel bio-active molecules | ABCG2, UGT2B7, UGT1A1 | KDM4E 4794/4885PLA2G10 3230/4885ALDH1A1 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.