Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809703 | 0.79 | MAOA (0.42) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL19582587 | 0.78 | HIF1A (0.47) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL8019722 | 0.75 | HIF1A (0.50) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL16314143 | 0.74 | RNASEH1 (0.37) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| Ammonia Solution, Strong SCHEMBL4359394 | 0.73 | MEN1 (0.44) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL5945476 | 0.71 | DAPK3 (0.36) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL4359389 | 0.71 | HTR2C (0.40) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| SCHEMBL7696846 | 0.69 | HIF1A (0.40) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| Fluorene SCHEMBL29355380 | 0.67 | MAOA (0.68) | MAOAMAPK8MAPK9PLK4DAPK3 | |
| Fluorene SCHEMBL29478468 | 0.67 | MAOA (0.68) | MAOAMAPK8MAPK9PLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268437-A1 | INHIBITORS OF PROTEIN KINASES | Knoll GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002030908-A1 | INHIBITORS OF PROTEIN KINASES | KNOLL GMBH (DE) | 2002-04-18 | — | — | WO | disclosed |