Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291203 | 0.84 | MCL1 (0.47) | MAPK1MCL1ALDH1A1KMT2ATLR4 | |
| SCHEMBL9665167 | 0.80 | NAAA (0.45) | LMNAMAPK1MCL1NAAATLR4 | |
| SCHEMBL7762851 | 0.80 | NAAA (0.45) | LMNAMAPK1MCL1NAAATLR4 | |
| SCHEMBL7757533 | 0.80 | NAAA (0.45) | LMNAMAPK1MCL1NAAATLR4 | |
| SCHEMBL8984610 | 0.79 | MCL1 (0.44) | MAPK1MCL1ALDH1A1NAAAKMT2A | |
| SCHEMBL29191656 | 0.78 | NAAA (0.42) | LMNAMAPK1MCL1ALDH1A1NAAA | |
| SCHEMBL9146338 | 0.78 | MAPK1 (0.44) | LMNAMAPK1MCL1ALDH1A1KMT2A | |
| SCHEMBL535448 | 0.76 | LMNA (0.45) | LMNAMAPK1MCL1ALDH1A1NAAA | |
| SCHEMBL8920483 | 0.76 | NPC1 (0.44) | LMNAAPOBEC3AAPOBEC3GALDH1A1NAAA | |
| SCHEMBL8984381 | 0.74 | EPHX2 (0.49) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725772-B1 | PHYTOSPHINGOSINE-BASED CERAMIDE I ANALOGS | COSMOFERM BV (NL) | 2003-08-20 | — | — | EP | disclosed |
| US-6054599-A | DRUGS, COSMETICS; SKIN DISORDERS | DSM N.V. (NL) | 2000-04-25 | — | — | US | disclosed |
| US-5919960-A | Phytosphingosine-based ceramide I analogs | GIST-BROCADES, B.V. (NL) | 1999-07-06 | — | — | US | disclosed |
| EP-0725772-A1 | PHYTOSPHINGOSINE-BASED CERAMIDE I ANALOGS | GIST-BROCADES B.V. (NL) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011881-A1 | PHYTOSPHINGOSINE-BASED CERAMIDE I ANALOGS | GIST-BROCADES N.V. (NL) | 1995-05-04 | — | — | WO | disclosed |