Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739797 | 0.84 | TSHR (0.51) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31145849 | 0.82 | TSHR (0.49) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL12190376 | 0.80 | NAMPT (0.49) | TSHRRAB9A | |
| SCHEMBL4153508 | 0.80 | TSHR (0.49) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1190850 | 0.80 | TSHR (0.49) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31563528 | 0.79 | KDM4C (0.59) | KDM4EL3MBTL1LMNAROCK2ROCK1 | |
| SCHEMBL12990781 | 0.79 | KDM4C (0.59) | KDM4EL3MBTL1LMNAROCK2ROCK1 | |
| SCHEMBL3899443 | 0.79 | TSHR (0.48) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5918078 | 0.79 | TSHR (0.48) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL12750476 | 0.79 | TSHR (0.55) | TSHRNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842924-A1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER INC. (US) | 1998-05-20 | — | — | EP | claimed |
| EP-4688748-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-20260008774-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2026-01-08 | — | — | US | disclosed |
| US-12448369-B2 | Quinolinone amide compounds and uses thereof | EDGEWISE THERAPEUTICS, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250026740-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. | 2025-01-23 | — | — | US | disclosed |
| WO-2024206339-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-10-03 | — | — | WO | disclosed |
| EP-0842924-B1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6031105-A | Substituted pyridines | PFIZER INC (US) | 2000-02-29 | — | — | US | disclosed |
| US-6008361-A | Substituted pyridines | PFIZER INC. (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0842924-A1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER INC. (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0480155-B1 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST ROUSSEL PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0480155-A2 | 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5095019-A | 4-substituted dihydropyrido(4,3-D)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| US-5059602-A | 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0435222-A2 | Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12448369-B2 | Quinolinone amide compounds and uses thereof | TNNI3, TNNT2, COQ8A | TSHR 3265/4885NPC1 1533/4885RAB9A 288/4885 |
| US-20250026740-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | TNNI3, TNNT2, COQ8A | TSHR 3265/4885NPC1 1533/4885RAB9A 288/4885 |
| US-20260008774-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | TNNT2, TNNI3, TNNC1 | TSHR 339/4885NPC1 304/4885RAB9A 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.