Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 16/20 | 0.72 |
| ▸ | ABCC8 | Q09428 | 16/20 | 0.72 |
| ▸ | KCNJ11 | Q14654 | 16/20 | 0.72 |
| ▸ | KCNJ8 | Q15842 | 16/20 | 0.72 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926386 | 0.92 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL4256078 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL29763183 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL3095468 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6431754 | 0.80 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL7097522 | 0.80 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8GAA | |
| SCHEMBL6909574 | 0.78 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL7094021 | 0.77 | ABCC9 (0.80) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7097781 | 0.77 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7836158 | 0.77 | ABCC9 (0.84) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |