Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 10/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 10/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 10/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 10/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928301 | 0.91 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7814727 | 0.83 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7011365 | 0.80 | ALDH1A1 (0.48) | KMT2AMEN1MAPTCACNA1CCACNA1F | |
| SCHEMBL7095360 | 0.80 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL6908037 | 0.79 | KMT2A (0.43) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7099788 | 0.78 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL6908767 | 0.78 | MEN1 (0.44) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7835693 | 0.76 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7097781 | 0.75 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7094021 | 0.75 | ABCC9 (0.80) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |