Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847828 | 0.83 | HDAC6 (0.53) | RAB9ASMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL5847797 | 0.79 | ALDH1A1 (0.47) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL3225126 | 0.78 | NPC1 (1.00) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6961822 | 0.77 | NPC1 (0.64) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL2956025 | 0.77 | NPC1 (0.68) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7105034 | 0.76 | LMNA (0.57) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6240951 | 0.76 | L3MBTL1 (0.46) | POLBKDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL8476710 | 0.76 | NPC1 (0.66) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL4930583 | 0.75 | NPC1 (0.64) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL4628943 | 0.74 | NPC1 (0.68) | NPC1RAB9APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001087852-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL URACILS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
| EP-1268428-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001077079-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | disclosed |