Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474796 | 0.81 | NPC1 (0.47) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL6908528 | 0.76 | MMP8 (0.64) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL8200333 | 0.76 | MMP8 (0.55) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL7845037 | 0.76 | DAO (0.40) | NPC1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7092555 | 0.73 | MMP8 (0.59) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL27676660 | 0.71 | MMP8 (0.54) | MMP8NPC1MEN1KMT2AMAPT | |
| SCHEMBL7925167 | 0.71 | MMP8 (0.47) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL2098734 | 0.71 | NPC1 (0.59) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL27715083 | 0.71 | NPC1 (0.59) | MMP8NPC1MEN1KMT2APIN1 | |
| SCHEMBL28226195 | 0.71 | NPC1 (0.59) | MMP8NPC1MEN1KMT2APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |