Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092555 | 0.92 | MMP8 (0.59) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL8200333 | 0.92 | MMP8 (0.55) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL7094136 | 0.89 | MMP8 (0.56) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL7093633 | 0.89 | MMP8 (0.52) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL7093345 | 0.88 | NPC1 (0.56) | MMP8MEN1NPC1KMT2AL3MBTL1 | |
| SCHEMBL266419 | 0.87 | MMP8 (0.74) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL27324944 | 0.87 | MMP8 (0.50) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL7095774 | 0.87 | MMP8 (0.50) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL27676660 | 0.87 | MMP8 (0.54) | MMP8MEN1NPC1KMT2ATSHR | |
| SCHEMBL13158250 | 0.86 | KMT2A (0.58) | MMP8MEN1NPC1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695127-B2 | Compounds for treating HIV and methods for using the compounds | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695127-B2 | Compounds for treating HIV and methods for using the compounds | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-15 | — | — | US | disclosed |
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-15 | — | — | US | disclosed |
| WO-2014074628-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-15 | — | — | WO | disclosed |
| US-6673923-B2 | PYRAZOLE AND PYRAZOLONE DERIVATIVES, USEFUL AS RNA POLYMERASE INHIBITORS AND ANTIBIOTICS | TULARIK INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020049205-A1 | Pyrazole antimicrobial agents | AMGEN INC. | 2002-04-25 | — | — | US | disclosed |
| WO-2001082930-A1 | PYRAZOLE ANTIMICROBIAL AGENTS | TULARIK INC. (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049205-A1 | Pyrazole antimicrobial agents | POLRMT, POLR1C, RNGTT | MMP8 2332/4885MEN1 4622/4885NPC1 1812/4885 |
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | PNMT, NEFM, DUT | MMP8 614/4885MEN1 4842/4885NPC1 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.