Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200333 | 0.94 | MMP8 (0.55) | MMP8NPC1MEN1KMT2ACA12 | |
| SCHEMBL6908528 | 0.92 | MMP8 (0.64) | MMP8NPC1MEN1KMT2ACYP3A4 | |
| SCHEMBL13228057 | 0.92 | MMP8 (0.47) | MMP8NPC1MEN1KMT2ACYP3A4 | |
| SCHEMBL13228059 | 0.89 | KMT2A (0.51) | MMP8NPC1MEN1KMT2ANPSR1 | |
| SCHEMBL7094136 | 0.88 | MMP8 (0.56) | MMP8NPC1MEN1KMT2ACA12 | |
| SCHEMBL2511176 | 0.87 | MMP8 (0.44) | MMP8MEN1KMT2ANPSR1CYP3A4 | |
| SCHEMBL7090828 | 0.85 | L3MBTL1 (0.52) | MMP8NPC1KMT2ACA12CA1 | |
| SCHEMBL13228075 | 0.85 | NAMPT (0.44) | MMP8NPC1MEN1KMT2ANPSR1 | |
| SCHEMBL13228049 | 0.85 | MMP8 (0.46) | MMP8MEN1KMT2ANPSR1LMNA | |
| SCHEMBL13228080 | 0.85 | LMNA (0.47) | MMP8MEN1KMT2ANPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |