Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28737712 | 0.84 | NPSR1 (0.54) | NPSR1GPR17HPGDCYP2C19KEAP1 | |
| SCHEMBL5842251 | 0.81 | NOTUM (0.45) | NOTUMALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL12466660 | 0.80 | ALDH1A1 (0.45) | NPSR1ALDH1A1GPR17HPGDCYP2C19 | |
| SCHEMBL969678 | 0.79 | NOTUM (0.48) | NOTUMALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL672247 | 0.76 | NPSR1 (0.56) | NPSR1ALDH1A1GPR17HPGDCYP2C19 | |
| SCHEMBL21751965 | 0.76 | NOTUM (0.54) | NOTUMALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL151413 | 0.75 | NPSR1 (0.61) | NPSR1NOTUMALDH1A1GPR17HPGD | |
| SCHEMBL70047 | 0.71 | NOTUM (0.65) | NOTUMALDH1A1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL29062 | 0.71 | FOLH1 (0.66) | NPSR1ALDH1A1HPGDKEAP1HTT | |
| SCHEMBL18496704 | 0.71 | NPSR1 (0.41) | NPSR1GPR17HPGDCYP2C19KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296975-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2003-04-02 | — | — | EP | claimed |
| WO-2002002551-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2002-01-10 | — | — | WO | claimed |