Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | HTR1D | P28221 | 4/20 | 0.40 |
| ▸ | HTR1B | P28222 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255669 | 0.79 | HTR6 (1.00) | HTR6HTR1A | |
| SCHEMBL5252115 | 0.77 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL13598936 | 0.67 | HTR6 (0.58) | HTR6NPSR1L3MBTL1HTR1AHTR1D | |
| SCHEMBL7103771 | 0.67 | HTR6 (0.45) | HTR6L3MBTL1HTR2ACYP2D6SLC6A2 | |
| SCHEMBL7164227 | 0.66 | PKM (0.47) | HTR6SLC6A2 | |
| SCHEMBL4427807 | 0.65 | HTR6 (0.53) | HTR6NPSR1L3MBTL1HTR1AHTR1D | |
| SCHEMBL13696908 | 0.65 | NPSR1 (0.62) | HTR6NPSR1L3MBTL1AKR1B1 | |
| SCHEMBL1548591 | 0.65 | NPSR1 (0.62) | HTR6NPSR1L3MBTL1AKR1B1 | |
| SCHEMBL337593 | 0.65 | NPSR1 (0.62) | NPSR1L3MBTL1AKR1B1 | |
| SCHEMBL3681454 | 0.65 | NPSR1 (0.59) | HTR6NPSR1L3MBTL1DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355904-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-10-29 | — | — | EP | claimed |
| WO-2002051837-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-07-04 | — | — | WO | claimed |