Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253204 | 0.78 | HTR6 (0.73) | HTR6HTR2A | |
| SCHEMBL5252125 | 0.74 | HTR6 (0.55) | HTR6HTR2A | |
| SCHEMBL7164227 | 0.69 | PKM (0.47) | HTR6MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2185861 | 0.68 | GRM4 (0.45) | HTR6HTR2AMEN1ALDH1A1TSHR | |
| SCHEMBL12809959 | 0.68 | HTR2C (0.66) | HTR6HTR2A | |
| SCHEMBL7096028 | 0.67 | HTR6 (0.66) | HTR6HTR2AL3MBTL1CYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL568208 | 0.66 | HTR2C (0.67) | HTR6HTR2A | |
| SCHEMBL3693533 | 0.66 | HTR2C (0.69) | HTR2A | |
| SCHEMBL15650799 | 0.65 | HTR2A (0.54) | HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL567713 | 0.65 | HTR2C (0.70) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355904-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-10-29 | — | — | EP | claimed |
| WO-2002051837-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-07-04 | — | — | WO | claimed |