Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807773 | 0.81 | SLC6A2 (0.59) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL91412 | 0.79 | TSHR (0.50) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL10912813 | 0.77 | TSHR (0.49) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL1021723 | 0.77 | TSHR (0.49) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL9665251 | 0.77 | SCN4A (0.51) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL1044925 | 0.76 | ACHE (0.46) | TSHRCYP1A2CYP3A4TP53ALDH1A1 | |
| SCHEMBL290801 | 0.76 | TTR (0.52) | TSHRCYP3A4SLC6A2SLC6A3TP53 | |
| SCHEMBL18195113 | 0.76 | TSHR (0.47) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL8678279 | 0.76 | TSHR (0.47) | TSHRHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL624403 | 0.76 | TSHR (0.47) | TSHRHTR2AHTR2CHTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | claimed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | claimed |
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN (US) | 2009-01-22 | — | — | US | claimed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | claimed |
| US-4707161-A | Lightfastness of dyeings obtained with acid dyes or metal complex dyes on polyamides: treatment with copper hydroxamates | BASF AKTIENGESELLSCHAFT (DE) | 1987-11-17 | — | — | US | claimed |
| US-4020061-A | 3-Oxomethyl-2-(1-nitro-2-oxoethylidene)-tetrahydro-2H-1,3-thiazines | SHELL OIL COMPANY (US) | 1977-04-26 | — | — | US | claimed |
| US-4008249-A | HERBICIDE, PLANT GROWTH REGULATOR | BASF AKTIENGESELLSCHAFT (DT) | 1977-02-15 | — | — | US | claimed |
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| EP-0254987-B1 | BENZOPHENONE ETHER-ESTERS AND PROCESS FOR IMPROVING THE LIGHT FASTNESS OF POLYESTER COLOURINGS BY THE USE OF BENZOPHENONE ETHER-ESTERS | BASF Aktiengesellschaft (DE) | 1992-03-04 | — | — | EP | disclosed |
| EP-0446740-A2 | Utilization of benzophenone-derivatives as antiluminous agents for aromatic polycarbonates and polyestercarbonates | BASF Aktiengesellschaft (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0017132-B1 | DYESTUFFS, THEIR PREPARATION AND UTILISATION | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |
| EP-0017132-A1 | Dyestuffs, their preparation and utilisation | BASF Aktiengesellschaft (DE) | 1980-10-15 | — | — | EP | disclosed |
| US-4138548-A | Acaricidal pyridinium salts | FISONS LIMITED (GB) | 1979-02-06 | — | — | US | disclosed |
| US-4125617-A | Acaricidal pyridinium salts | FISONS LIMITED (GB) | 1978-11-14 | — | — | US | disclosed |
| US-4020061-A | 3-Oxomethyl-2-(1-nitro-2-oxoethylidene)-tetrahydro-2H-1,3-thiazines | SHELL OIL COMPANY (US) | 1977-04-26 | — | — | US | disclosed |
| US-4013669-A | ESTER-PYRIDINIUM COMPOUNDS AS ACARICIDES | FISONS LIMITED (EN) | 1977-03-22 | — | — | US | disclosed |
| US-4008249-A | HERBICIDE, PLANT GROWTH REGULATOR | BASF AKTIENGESELLSCHAFT (DT) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | TRPV1, SCN1A, SCN2A | TSHR 4445/4885HTR2A 1260/4885HTR2C 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.