Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606377 | 0.79 | HTR2A (0.38) | DRD2DRD3HTR2AHTR2CSLC6A2 | |
| SCHEMBL5606375 | 0.79 | HTR2A (0.38) | DRD2DRD3HTR2AHTR2CSLC6A2 | |
| SCHEMBL8558213 | 0.76 | MAPT (0.40) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL6466632 | 0.74 | HTR2A (0.40) | DRD2DRD3HTR2AHTR2CSLC6A2 | |
| SCHEMBL6466626 | 0.74 | HTR2A (0.40) | DRD2DRD3HTR2AHTR2CSLC6A2 | |
| SCHEMBL6254049 | 0.72 | LMNA (0.39) | DRD2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5598374 | 0.72 | SLC6A2 (0.32) | NOTUMADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22411187 | 0.72 | SIGMAR1 (0.39) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL22410973 | 0.69 | SLC6A2 (0.36) | ADRB1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL22410972 | 0.69 | SLC6A2 (0.36) | ADRB1SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339696-A1 | BENZYL(IDENE)-LACTAMS AND THEIR USE AS 5HT1-RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002046167-A1 | BENZYL (IDENE)-LACTAMS AND THEIR USE AS 5HT1-RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2002-06-13 | — | — | WO | disclosed |