Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | BRD2 | P25440 | 2/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101360 | 0.80 | BLM (0.54) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL12257284 | 0.78 | PDE4A (0.80) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL10813831 | 0.77 | PDE4A (0.83) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL10571805 | 0.76 | PDE4A (0.78) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7099928 | 0.76 | ADORA2B (0.50) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7781761 | 0.76 | KDM4E (0.39) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL29474230 | 0.75 | PDE4A (0.70) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL2462137 | 0.74 | PDE4A (0.69) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7100345 | 0.73 | ADORA2B (0.50) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL32679497 | 0.73 | PDE4A (0.68) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140952-B1 | ORGANO-PHOSPHORUS COMPOUNDS AND THEIR UTILIZATION | BIOAGENCY AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-1140952-A1 | ORGANO-PHOSPHORUS COMPOUNDS AND THEIR UTILIZATION | Jomaa Pharmaka GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037477-A1 | ORGANO-PHOSPHORUS COMPOUNDS AND THEIR UTILIZATION | JOMAA PHARMAKA GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |