SCHEMBL7096880

SCHEMBL7096880

COc1ccccc1C=CC(=O)c1cccc(N)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.74
MAPT P10636 4/20 0.72
NPC1 O15118 3/20 0.72
LMNA P02545 2/20 0.72
RAB9A P51151 2/20 0.72
BCHE P06276 1/20 0.72
PTPN1 P18031 1/20 0.67
RELA Q04206 1/20 0.66
MAOB P27338 4/20 0.63
CYP1A2 P05177 3/20 0.61
CYP2D6 P10635 3/20 0.61
CYP1A1 P04798 2/20 0.61
CYP1B1 Q16678 2/20 0.61
CYP3A4 P08684 2/20 0.61
CYP2C9 P11712 1/20 0.61
HPGD P15428 1/20 0.61
CYP2C19 P33261 1/20 0.61
RECQL P46063 1/20 0.61
GPR55 Q9Y2T6 1/20 0.61
NFE2L2 Q16236 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7100872 0.90 MAOB (0.69) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL7097238 0.86 PTPN1 (0.74) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL7096493 0.86 ABCG2 (0.70) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL29395318 0.86 CTSL (0.75) NR1H4MAPTNPC1RAB9APTPN1
SCHEMBL20563578 0.86 CTSL (0.75) NR1H4MAPTNPC1RAB9APTPN1
SCHEMBL7099971 0.86 MAPT (0.74) MAPTNPC1LMNARAB9APTPN1
SCHEMBL7097534 0.86 ABCG2 (0.71) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL22721804 0.86 ABCG2 (0.71) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL29391850 0.86 ABCG2 (0.71) NR1H4MAPTNPC1LMNARAB9A
SCHEMBL7100434 0.86 MAPT (0.64) NR1H4MAPTNPC1LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO claimed
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO disclosed