SCHEMBL7096493

SCHEMBL7096493

COc1cccc(OC)c1C=CC(=O)c1cccc(N)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 5/20 0.70
PTPN1 P18031 1/20 0.62
ABCB1 P08183 2/20 0.55
NR1H4 Q96RI1 2/20 0.54
CYP1A2 P05177 2/20 0.53
CYP1A1 P04798 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAOA P21397 2/20 0.52
NPC1 O15118 1/20 0.51
LMNA P02545 1/20 0.51
BCHE P06276 1/20 0.51
MAPT P10636 1/20 0.51
RAB9A P51151 1/20 0.51
KRAS P01116 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
AURKA O14965 1/20 0.50
RELA Q04206 1/20 0.49
CA1 P00915 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7102437 0.91 ABCG2 (0.70) ABCG2PTPN1ABCB1NR1H4MAOA
SCHEMBL7096880 0.86 NR1H4 (0.74) PTPN1ABCB1NR1H4CYP1A2CYP1A1
SCHEMBL7101379 0.85 ABCG2 (0.85) ABCG2PTPN1CYP1A2CYP1A1CYP2D6
SCHEMBL7192430 0.85 ABCG2 (0.85) ABCG2PTPN1CYP1A2CYP1A1CYP2D6
SCHEMBL7100872 0.84 MAOB (0.69) ABCG2PTPN1ABCB1NR1H4CYP1A2
SCHEMBL7097238 0.83 PTPN1 (0.74) ABCG2PTPN1ABCB1NR1H4NPC1
SCHEMBL979720 0.83 ABCG2 (0.87) ABCG2NR1H4CYP1A2CYP1A1CYP2D6
SCHEMBL979719 0.83 ABCG2 (0.87) ABCG2NR1H4CYP1A2CYP1A1CYP2D6
SCHEMBL14760795 0.82 ABCB1 (0.82) ABCG2ABCB1CYP1A2CYP1A1CYP2D6
SCHEMBL16257539 0.82 NR1H4 (0.74) ABCG2ABCB1NR1H4CYP1A2CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO claimed
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO disclosed