SCHEMBL7096884

SCHEMBL7096884

CC(C)COC(=O)C(C)C(=O)C(C)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.42
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.33
TDP1 Q9NUW8 3/20 0.33
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
NPC1 O15118 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.31
P2RX4 Q99571 1/20 0.31
MAPK1 P28482 2/20 0.30
GAA P10253 1/20 0.30
NR1H3 Q13133 1/20 0.30
KDM4E B2RXH2 1/20 0.30
HSD17B10 Q99714 1/20 0.30
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
NFKB1 P19838 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7097417 0.82 TSHR (0.38) TSHRALDH1A1SMN1; SMN2
SCHEMBL22883297 0.81 TSHR (0.48) TSHRALDH1A1SMN1; SMN2TDP1RAB9A
SCHEMBL2275427 0.81 TSHR (0.52) TSHRALDH1A1SMN1; SMN2TDP1RAB9A
SCHEMBL6247104 0.80 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2TDP1MAPTNPC1
SCHEMBL7102235 0.79 TSHR (0.36) TSHRALDH1A1SMN1; SMN2MAPT
SCHEMBL7101682 0.77 ALDH1A1 (0.36) TSHRALDH1A1TDP1MAPTMAPK1
SCHEMBL27888652 0.77 TSHR (0.48) TSHRALDH1A1SMN1; SMN2TDP1RAB9A
SCHEMBL7099734 0.76 MAPT (0.41) TSHRALDH1A1TDP1MAPTL3MBTL1
SCHEMBL9478200 0.75 TSHR (0.52) TSHRALDH1A1SMN1; SMN2TDP1RAB9A
SCHEMBL7096981 0.75 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1038861-B1 4-FLUORO-3-OXOCARBOXYLIC ESTERS AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES (JP) 2003-09-03 EP disclosed
US-6593488-B1 Reacting 2-fluorocarboxylate with carboxylate UBE INDUSTRIES, LTD. (JP) 2003-07-15 US disclosed
EP-1038861-A1 4-FLUORO-3-OXOCARBOXYLIC ESTERS AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES LIMITED (JP) 2000-09-27 EP disclosed