Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642308 | 0.89 | KDM4E (0.47) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL6686729 | 0.88 | NTRK1 (0.58) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL13341887 | 0.85 | SMN1; SMN2 (0.56) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL13341895 | 0.85 | NPC1 (0.56) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL22780401 | 0.83 | NTRK1 (0.57) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL13341897 | 0.82 | GABRB2 (0.62) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL13341900 | 0.82 | ALDH1A1 (0.61) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL3613601 | 0.80 | SLC2A2 (0.69) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8208 | 0.79 | KDM4E (0.64) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL9242819 | 0.79 | NPC1 (0.59) | NTRK1CYP1A2CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1172364-B1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | DINAMITE DIPHARMA S P A IN ABB (IT) | 2003-04-23 | — | — | EP | claimed |
| US-6384226-B2 | REACTING 2-PHENYL-IMIDAZOLO(1,2-A)PYRIDINE WITH OXALIC ACID ESTER; REDUCTION; AMIDATION | DINAMITE DIPHARMA S.P.A. (IT) | 2002-05-07 | — | — | US | claimed |
| US-20020019528-A1 | Process for the preparation of 2-phenyl-imidazo [1, 2-a] pyridine-3-acetamides | DINAMITE DIPHARMA S.P.A. | 2002-02-14 | — | — | US | claimed |
| EP-1172364-A1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | Dinamite Dipharma S.p.A. (in abbreviated form Dipharma S.p.A.) (IT) | 2002-01-16 | — | — | EP | claimed |
| EP-1172364-B1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | DINAMITE DIPHARMA S P A IN ABB (IT) | 2003-04-23 | — | — | EP | disclosed |
| EP-1172364-B1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | DINAMITE DIPHARMA S P A IN ABB (IT) | 2003-04-23 | — | — | EP | disclosed |
| JP-2002167385-A | MANUFACTURING METHOD OF 2-PHENYLIMIDAZO[1,2a]PYRIDINE-3- ACETAMIDES | DINAMITE DIPHARMA SPA ABBREVIATED DIPHARMA SPA | 2002-06-11 | — | — | JP | disclosed |
| US-6384226-B2 | REACTING 2-PHENYL-IMIDAZOLO(1,2-A)PYRIDINE WITH OXALIC ACID ESTER; REDUCTION; AMIDATION | DINAMITE DIPHARMA S.P.A. (IT) | 2002-05-07 | — | — | US | disclosed |
| US-6384226-B2 | REACTING 2-PHENYL-IMIDAZOLO(1,2-A)PYRIDINE WITH OXALIC ACID ESTER; REDUCTION; AMIDATION | DINAMITE DIPHARMA S.P.A. (IT) | 2002-05-07 | — | — | US | disclosed |
| US-20020019528-A1 | Process for the preparation of 2-phenyl-imidazo [1, 2-a] pyridine-3-acetamides | DINAMITE DIPHARMA S.P.A. | 2002-02-14 | — | — | US | disclosed |
| US-20020019528-A1 | Process for the preparation of 2-phenyl-imidazo [1, 2-a] pyridine-3-acetamides | DINAMITE DIPHARMA S.P.A. | 2002-02-14 | — | — | US | disclosed |
| EP-1172364-A1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | Dinamite Dipharma S.p.A. (in abbreviated form Dipharma S.p.A.) (IT) | 2002-01-16 | — | — | EP | disclosed |
| EP-1172364-A1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | Dinamite Dipharma S.p.A. (in abbreviated form Dipharma S.p.A.) (IT) | 2002-01-16 | — | — | EP | disclosed |
| EP-1172364-A1 | A process for the preparation of 2-phenyl-imidazo[1,2-A]pyridine-3-acetamides | Dinamite Dipharma S.p.A. (in abbreviated form Dipharma S.p.A.) (IT) | 2002-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019528-A1 | Process for the preparation of 2-phenyl-imidazo [1, 2-a] pyridine-3-acetamides | OTC, ODC1, OXGR1 | NTRK1 1921/4885CYP1A2 114/4885CYP2C9 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.