Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 13/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 13/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 11/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093023 | 0.84 | ALDH1A1 (0.66) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL7099723 | 0.81 | ABCC9 (0.61) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL5012649 | 0.79 | ALDH1A1 (0.54) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL7099312 | 0.79 | ABCC9 (0.62) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL7852242 | 0.75 | ABCC9 (0.72) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7096837 | 0.73 | ALDH1A1 (0.52) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL8186663 | 0.72 | GSK3B (0.55) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL28456116 | 0.72 | CA1 (0.41) | ALDH1A1KDM4EMAPTRECQLLMNA | |
| SCHEMBL5813926 | 0.72 | GSK3B (0.58) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL7099164 | 0.72 | CACNA1C (0.51) | ABCC9KCNJ11ABCC8KCNJ8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |