Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | ABCC9 | O60706 | 9/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813926 | 0.86 | GSK3B (0.58) | ALDH1A1KDM4EMAPTLMNAHPGD | |
| SCHEMBL7097111 | 0.84 | ABCC9 (0.50) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL5012649 | 0.83 | ALDH1A1 (0.54) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7096837 | 0.83 | ALDH1A1 (0.52) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL6296874 | 0.82 | ALDH1A1 (0.53) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7099081 | 0.81 | ALDH1A1 (0.66) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7379319 | 0.80 | ALDH1A1 (0.73) | ALDH1A1KDM4EMAPTLMNAHPGD | |
| SCHEMBL10648966 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTRAB9ALMNA | |
| SCHEMBL7102178 | 0.78 | ALDH1A1 (0.48) | ALDH1A1ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL9866867 | 0.78 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |