Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | STAT1 | P42224 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22106289 | 0.90 | MAOB (0.59) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL31260258 | 0.90 | MAOA (0.81) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL7107987 | 0.90 | MAOA (0.81) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13563997 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10649359 | 0.88 | MAPT (0.71) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL85996 | 0.87 | MAOB (0.62) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3661536 | 0.87 | NPC1 (0.83) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13356708 | 0.87 | NPC1 (0.57) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| Nitrogen SCHEMBL8497934 | 0.87 | MAOA (0.76) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16809332 | 0.85 | MAPT (0.68) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030040538-A1 | Novel substituted tricyclic compounds | ASAHI-KASEI KABUSHIKI KAISHA (JP) | 2003-02-27 | — | — | US | disclosed |
| US-20030018061-A1 | Novel remedies with the use of beta 3 agonist | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2003-01-23 | — | — | US | disclosed |
| EP-1258253-A1 | NOVEL REMEDIES WITH THE USE OF BETA3 AGONIST | Asahi Kasei Kabushiki Kaisha (JP) | 2002-11-20 | — | — | EP | disclosed |
| EP-1238973-A1 | NOVEL SUBSTITUTED TRICYCLIC COMPOUNDS | Asahi Kasei Kabushiki Kaisha (JP) | 2002-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040538-A1 | Novel substituted tricyclic compounds | CPT1A, CBR1, NR1H3 | KDM4E 1429/4885ALDH1A1 1241/4885MAPT 4835/4885 |
| US-20030018061-A1 | Novel remedies with the use of beta 3 agonist | ADRB3, GBA3, HMGCR | KDM4E 4169/4885ALDH1A1 458/4885MAPT 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.