SCHEMBL3661536

SCHEMBL3661536

COc1ccc2c(=O)c3ccc(OC)cc3oc2c1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.83
RAB9A P51151 3/20 0.83
MAOA P21397 3/20 0.83
ALDH1A1 P00352 8/20 0.72
KDM4E B2RXH2 7/20 0.72
MAPT P10636 5/20 0.72
HPGD P15428 5/20 0.72
CASP3 P42574 1/20 0.72
SMN1; SMN2 Q16637 1/20 0.72
SENP8 Q96LD8 1/20 0.72
SENP7 Q9BQF6 1/20 0.72
SENP6 Q9GZR1 1/20 0.72
POLB P06746 1/20 0.66
STAT1 P42224 1/20 0.66
HSD17B10 Q99714 4/20 0.64
CA1 P00915 3/20 0.62
CA2 P00918 3/20 0.62
MEN1 O00255 2/20 0.62
CYP3A4 P08684 2/20 0.62
KMT2A Q03164 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331388 0.93 KDM4E (0.86) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL29958722 0.91 MAOA (1.00) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL9078491 0.91 NPC1 (0.71) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL789950 0.91 MAOA (1.00) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL8867576 0.90 MAOA (0.69) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL11367852 0.90 MAOA (0.69) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL490107 0.90 MAOA (0.69) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL17037021 0.90 NPC1 (0.69) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL20329619 0.88 NPC1 (0.68) NPC1RAB9AMAOAALDH1A1KDM4E
SCHEMBL20317211 0.88 NPC1 (0.77) NPC1RAB9AMAOAALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3994125-B1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF REGENERON PHARMA (US) 2025-12-24 EP disclosed
US-11957687-B2 Modulators of HSD17B13 and methods of use thereof REGENERON PHARMACEUTICALS, INC. (US) 2024-04-16 US disclosed
US-20230094341-A1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2023-03-30 US disclosed
EP-3994125-A1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF Regeneron Pharmaceuticals, Inc. (US) 2022-05-11 EP disclosed
WO-2021003295-A1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2021-01-07 WO disclosed
WO-2021003295-A1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2021-01-07 WO disclosed
EP-3109703-B1 PHOTOSENSITIZATION CHEMICAL-AMPLIFICATION TYPE RESIST MATERIAL, AND METHOD FOR FORMING PATTERN USING SAME TOKYO ELECTRON LTD (JP) 2020-12-30 EP disclosed
CN-110664816-A SECA inhibitors and methods of making and using the same 佐治亚州立大学研究基金会公司 2020-01-10 CN disclosed
EP-3339395-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2019-10-02 EP disclosed
US-10025187-B2 Photosensitization chemical-amplification type resist material, method for forming pattern using same, semiconductor device, mask for lithography, and template for nanoimprinting TOKYO ELECTRON LIMITED (JP) 2018-07-17 US disclosed
US-20080286484-A1 INK COMPOSITION, INKJET RECORDING METHOD, AND PRINTED MATERIAL FUJIFILM CORPORATION (JP) 2008-11-20 US disclosed
US-20080227024-A1 PHOTOSENSITIVE COMPOSITION, AND CURED RELIEF PATTERN PRODUCTION METHOD AND SEMICONDUCTOR DEVICE USING THE SAME FUJIFILM CORPORATION (JP) 2008-09-18 US disclosed
US-20080227024-A1 PHOTOSENSITIVE COMPOSITION, AND CURED RELIEF PATTERN PRODUCTION METHOD AND SEMICONDUCTOR DEVICE USING THE SAME FUJIFILM CORPORATION (JP) 2008-09-18 US disclosed
US-20080206527-A1 INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, AND INK SET FUJIFILM CORPORATION (JP) 2008-08-28 US disclosed
US-20080206527-A1 INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, AND INK SET FUJIFILM CORPORATION (JP) 2008-08-28 US disclosed
US-5623080-A Fluorone and pyronin Y derivatives SPECTRA GROUP LIMITED, INC. (US) 1997-04-22 US disclosed
US-5495005-A ANTICOAGULANTS, CARDIOVASCULAR DISORDERS NATIONAL SCIENCE COUNCIL (TW) 1996-02-27 US disclosed
US-5451343-A Photoinitiators SPECTRA GROUP LIMITED, INC. (US) 1995-09-19 US disclosed
WO-1995014689-A1 FLUORONE AND PYRONIN Y DERIVATIVES SPECTRA GROUP LIMITED, INC. (US) 1995-06-01 WO disclosed
US-4267344-A 3-PENTA/ALKOXY/BENZYL-; -XANTHYL-, -THIOXANTHYL-, OR -SELENOXANTHYLOXAZOLIDINE-2,5-DIONES PROTEINKEMISK INSTITUT. TILKNYTTET AKADEMIET FOR DE TEKNISKE VIDENSKABER (DK) 1981-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10025187-B2 Photosensitization chemical-amplification type resist material, method for forming pattern using same, semiconductor device, mask for lithography, and template for nanoimprinting ASIC1, ASIC3, CLTA NPC1 3366/4885RAB9A 2483/4885MAOA 1735/4885
US-20230094341-A1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF HSD17B3, HSD17B11, HSD17B1 NPC1 404/4885RAB9A 3998/4885MAOA 1875/4885
US-11957687-B2 Modulators of HSD17B13 and methods of use thereof HSD17B3, HSD17B11, HSD17B1 NPC1 404/4885RAB9A 3998/4885MAOA 1875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.