SCHEMBL7097439

SCHEMBL7097439

COc1ccc(Cc2c(N)nc(S)nc2N)cc1.[KH]

nearest known ligand 0.73

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.73
CYP2D6 P10635 1/20 0.73
ATM Q13315 1/20 0.73
NPSR1 Q6W5P4 1/20 0.51
LMNA P02545 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
IDO1 P14902 2/20 0.47
HTR2A P28223 3/20 0.46
HTR2C P28335 3/20 0.46
LTA4H P09960 2/20 0.46
HPGD P15428 1/20 0.45
POLB P06746 1/20 0.44
DHFR P00374 1/20 0.42
MPO P05164 1/20 0.41
AGXT P21549 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7093887 0.78 HSP90AB1 (0.45) ALDH1A1CYP2D6ATMSMN1; SMN2IDO1
SCHEMBL8376201 0.77 ALDH1A1 (0.68) ALDH1A1CYP2D6ATMNPSR1LMNA
Hydrochloric Acid SCHEMBL7522555 0.77 ALDH1A1 (0.68) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL23612255 0.76 ALDH1A1 (0.82) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL30055740 0.76 ALDH1A1 (0.82) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL7093994 0.75 ALDH1A1 (0.45) ALDH1A1CYP2D6ATMSMN1; SMN2IDO1
SCHEMBL34461806 0.75 ALDH1A1 (0.65) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL7098438 0.75 DHFR (0.52) ALDH1A1HTR2AHTR2CDHFR
SCHEMBL8097615 0.75 ALDH1A1 (0.65) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL28585742 0.74 ALDH1A1 (0.64) ALDH1A1CYP2D6ATMNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194415-B1 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION EGYT GYOGYSZERVEGYESZETI GYAR (HU) 2003-08-20 EP disclosed
US-6469168-B1 FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY ANXIETY EGIS Gyógyszergyár Rt. (HU) 2002-10-22 US disclosed
EP-1194415-A2 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION Egis Gyogyszergyar Rt. (HU) 2002-04-10 EP disclosed
WO-2001000617-A2 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE SAME EGIS Gyógyszergyár Rt. (HU) 2001-01-04 WO disclosed