SCHEMBL8376201

SCHEMBL8376201

CCSc1nc(N)c(Cc2ccc(OC)cc2)c(N)n1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.68
CYP2D6 P10635 1/20 0.68
ATM Q13315 1/20 0.68
HTR2A P28223 3/20 0.57
HTR2C P28335 3/20 0.57
NPSR1 Q6W5P4 1/20 0.48
LMNA P02545 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HPGD P15428 3/20 0.43
LTA4H P09960 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
POLB P06746 1/20 0.41
HEXA P06865 1/20 0.40
HEXB P07686 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
RECQL P46063 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8379832 0.81 ADORA2A (0.50) ALDH1A1CYP2D6ATMHTR2AHTR2C
SCHEMBL8375810 0.79 ALDH1A1 (0.46) ALDH1A1CYP2D6ATMHTR2AHTR2C
SCHEMBL7097439 0.77 ALDH1A1 (0.73) ALDH1A1CYP2D6ATMHTR2AHTR2C
SCHEMBL8380917 0.74 HTR2A (0.54) HTR2AHTR2CSMN1; SMN2LTA4HIDO1
Hydrochloric Acid SCHEMBL7522555 0.73 ALDH1A1 (0.68) ALDH1A1CYP2D6ATMNPSR1LMNA
Hydrochloric Acid SCHEMBL7097609 0.73 HTR2A (0.62) ALDH1A1CYP2D6ATMHTR2AHTR2C
SCHEMBL23612255 0.73 ALDH1A1 (0.82) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL30055740 0.73 ALDH1A1 (0.82) ALDH1A1CYP2D6ATMNPSR1LMNA
SCHEMBL34461806 0.72 ALDH1A1 (0.65) ALDH1A1CYP2D6ATMHTR2AHTR2C
SCHEMBL8097615 0.71 ALDH1A1 (0.65) ALDH1A1CYP2D6ATMNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901473-A1 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS EGIS GYOGYSZERGYAR RT. (HU) 1999-03-17 EP disclosed
WO-1997016429-A1 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS EGIS Gyógyszergyár Rt. (HU) 1997-05-09 WO disclosed