Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098597 | 0.77 | NOTUM (0.54) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7097558 | 0.74 | MAPK1 (0.57) | NOTUMMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7097840 | 0.73 | ALDH1A1 (0.65) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2554923 | 0.71 | NOTUM (0.60) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2561801 | 0.70 | KMT2A (0.56) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2564545 | 0.68 | MAPT (0.62) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14096013 | 0.66 | ALDH1A1 (0.65) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL10998715 | 0.65 | RAB9A (0.64) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL15330595 | 0.65 | NPC1 (0.65) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2559946 | 0.65 | MAPK1 (0.59) | NOTUMALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339668-A2 | BISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIRUS | GUILFORD PHARMACEUTICALS INC. (US) | 2003-09-03 | — | — | EP | claimed |
| WO-2002044126-A2 | BISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIRUS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-06-06 | — | — | WO | claimed |