Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.50 |
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15972776 | 1.00 | ALDH1A1 (0.60) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL29195204 | 0.86 | ELANE (0.46) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL21379715 | 0.82 | ALDH1A1 (0.43) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL9584263 | 0.82 | SMN1; SMN2 (0.68) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL10131015 | 0.80 | CYP3A4 (0.53) | ALDH1A1ADAM17MMP13CYP3A4SMN1; SMN2 | |
| SCHEMBL5182781 | 0.80 | ALDH1A1 (0.46) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL5182263 | 0.80 | ALDH1A1 (0.46) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL542639 | 0.80 | SMN1; SMN2 (0.73) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL944078 | 0.78 | ALDH1A1 (0.57) | ALDH1A1ADAM17MMP2MMP9MMP13 | |
| SCHEMBL940446 | 0.78 | ALDH1A1 (0.57) | ALDH1A1ADAM17MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037672-B1 | PROCESS FOR THE PREPARATION OF CHIRAL HYDANTOINS, AND A NOVEL HYDANTOIN PRODUCED BY SAID PROCESS AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | PFIZER INC. (US) | 1986-05-14 | — | — | EP | claimed |
| JP-2276586-A | — | — | None | — | — | JP | disclosed |
| JP-2119796-A | — | — | None | — | — | JP | disclosed |
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3461816-B1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-24 | — | — | EP | disclosed |
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3461816-A1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-12-28 | — | — | US | disclosed |
| US-9840471-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2015-12-31 | — | — | US | disclosed |
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| EP-0725142-B1 | PROCESS FOR PRODUCING D-AMINO ACID BY USING COMPOSITE IMMOBILIZED ENZYME PREPARATION | KANEGAFUCHI CHEMICAL IND (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-5552318-A | ENANTIOSELECTIVE SYNTHESIS OF D-AMINO ACIDS | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1996-09-03 | — | — | US | disclosed |
| US-5552317-A | POLYMERIZATION OF MONOMERS IN THE PRESENCE OF ENZYME AND HYDROLYSIS | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 1996-09-03 | — | — | US | disclosed |
| JP-H02276586-A | PRODUCTION OF D-HOMOPHENYLALANINE | BIO-LE KK | 1990-11-13 | — | — | JP | disclosed |
| JP-H02119796-A | PRODUCTION OF L-HOMOPHENYLALANINE | BIO-LE KK | 1990-05-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | ALDH1A1 1692/4885ADAM17 3914/4885MMP2 4601/4885 |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | ALDH1A1 1692/4885ADAM17 3914/4885MMP2 4601/4885 |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | ALDH1A1 1692/4885ADAM17 3914/4885MMP2 4601/4885 |
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | ALDH1A1 1692/4885ADAM17 3914/4885MMP2 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.