SCHEMBL7097818

SCHEMBL7097818

Cc1ccc(S(=O)(=O)N2CCC[C@H](NC(=O)OC(C)(C)C)CC2=O)cc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.45
ALDH1A1 P00352 3/20 0.45
EPHX2 P34913 2/20 0.45
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
MMP2 P08253 1/20 0.41
USP2 O75604 1/20 0.41
MAPK1 P28482 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
GAA P10253 2/20 0.40
CTSK P43235 2/20 0.40
NAMPT P43490 1/20 0.40
HPGD P15428 1/20 0.40
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508846 0.80 LMNA (0.66) LMNAALDH1A1EPHX2MEN1KMT2A
SCHEMBL2511290 0.78 LMNA (0.45) LMNAALDH1A1EPHX2MEN1KMT2A
SCHEMBL22868377 0.73 KMT2A (0.61) LMNAEPHX2USP2MAPK1MEN1
SCHEMBL13189171 0.73 USP2 (0.54) LMNAALDH1A1EPHX2CA1CA2
SCHEMBL25271793 0.72 BTK (0.49) LMNAALDH1A1EPHX2KMT2AGAA
SCHEMBL16899708 0.72 BTK (0.49) LMNAALDH1A1EPHX2KMT2AGAA
SCHEMBL19961527 0.72 POLB (0.47) ALDH1A1MMP2MEN1KMT2AGAA
SCHEMBL3317089 0.71 CA1 (0.59) EPHX2CA1CA2KMT2ACTSK
SCHEMBL3317093 0.71 CA1 (0.59) EPHX2CA1CA2KMT2ACTSK
SCHEMBL7072473 0.71 MMP2 (0.51) ALDH1A1CA1CA2MMP2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815084-B1 LACTAM-CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEASE PROCTER & GAMBLE (US) 2003-08-27 EP disclosed
EP-0815084-A1 LACTAM-CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEASE THE PROCTER & GAMBLE COMPANY (US) 1998-01-07 EP disclosed
US-5672598-A MATRIX METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1997-09-30 US disclosed
WO-1996029313-A1 LACTAM-CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEASE THE PROCTER & GAMBLE COMPANY (US) 1996-09-26 WO disclosed