Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2510502 | 0.93 | EPHX2 (0.47) | LMNAKMT2ATSHRMAPTNPC1 | |
| SCHEMBL2988382 | 0.83 | RORC (0.49) | EPHX2 | |
| SCHEMBL2516744 | 0.80 | ALDH1A1 (0.39) | LMNAKMT2ATSHRMAPTNPC1 | |
| SCHEMBL29508846 | 0.80 | LMNA (0.66) | LMNAKMT2ANPC1ALDH1A1MEN1 | |
| SCHEMBL2517731 | 0.78 | RORC (0.47) | EPHX2DRD2 | |
| SCHEMBL7097818 | 0.78 | LMNA (0.45) | LMNAKMT2AALDH1A1MEN1EPHX2 | |
| SCHEMBL2520300 | 0.78 | RORC (0.52) | LMNAKMT2ATSHRMAPTNPC1 | |
| SCHEMBL17215668 | 0.76 | MCL1 (0.62) | LMNAKMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL16814165 | 0.74 | MAPT (0.41) | LMNAKMT2AMAPTMEN1HCRTR1 | |
| SCHEMBL17158232 | 0.74 | ALDH1A1 (0.61) | LMNAKMT2AALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273754-B2 | Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds | ARQULE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273754-B2 | Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds | ARQULE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| EP-2379556-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078430-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010078430-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | DPYD, MKI67, TYMP | LMNA 2142/4885KMT2A 1835/4885TSHR 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.