Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 14/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342707 | 0.91 | KDR (0.53) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL7101583 | 0.85 | RAF1 (0.66) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL7102392 | 0.80 | RAF1 (0.60) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL7104626 | 0.78 | MEN1 (0.49) | MEN1RAB9AKMT2AMAPK14KDR | |
| SCHEMBL7013839 | 0.78 | KDR (0.54) | MEN1KMT2AMAPK14RAF1KDR | |
| SCHEMBL5348217 | 0.78 | RAF1 (0.64) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL668678 | 0.77 | FLT3 (0.73) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL7018064 | 0.76 | CDK8 (0.56) | MEN1RAB9AKMT2AMAPK14FLT3 | |
| SCHEMBL6235584 | 0.75 | LMNA (0.62) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL7102856 | 0.75 | MEN1 (0.47) | MEN1KMT2AMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |