Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | TEK | Q02763 | 6/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | VSIG8 | P0DPA2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345802 | 0.92 | LMNA (0.57) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL14375459 | 0.84 | LMNA (0.69) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL7012558 | 0.83 | KDR (0.55) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL7013839 | 0.82 | KDR (0.54) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL7102856 | 0.80 | MEN1 (0.47) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL5348784 | 0.79 | KDR (0.67) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL6235584 | 0.79 | LMNA (0.62) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL11879658 | 0.79 | LMNA (0.66) | MEN1KMT2ALMNANR1I2CYP1A2 | |
| SCHEMBL7097935 | 0.78 | MEN1 (0.53) | MEN1KMT2AMAPK14KDRRAB9A | |
| SCHEMBL26115475 | 0.78 | USP2 (0.54) | MEN1KMT2ALMNANR1I2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |