SCHEMBL7098026

SCHEMBL7098026

CCN(CC)CCCCNc1ccc2ccc(Cl)cc2n1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.48
KDR P35968 2/20 0.48
CCR4 P51679 2/20 0.48
CACNA2D1 P54289 1/20 0.47
CDK1 P06493 1/20 0.46
KDM4E B2RXH2 2/20 0.46
HSD17B10 Q99714 2/20 0.46
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46
FLT3 P36888 5/20 0.44
SLC2A1 P11166 1/20 0.44
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9113927 0.79 CYP2D6 (0.60) CCR4KDM4EHSD17B10LMNAHTT
SCHEMBL19386243 0.75 CACNA2D1 (0.52) FGFR1KDRCACNA2D1CDK1SLC2A1
SCHEMBL1147601 0.73 KDM4E (0.84) CDK1KDM4EHSD17B10LMNAHTT
SCHEMBL1147600 0.73 KDM4E (0.82) CDK1KDM4EHSD17B10LMNAHTT
SCHEMBL1147663 0.73 KDM4E (0.82) CDK1KDM4EHSD17B10LMNAHTT
SCHEMBL5394802 0.72 TERT (0.56) FGFR1KDRCACNA2D1KDM4EFLT3
SCHEMBL5189439 0.72 LMNA (0.64) CCR4CDK1KDM4EHSD17B10LMNA
SCHEMBL5943593 0.72 TP53 (0.42) FGFR1KDRCACNA2D1FLT3SLC2A1
SCHEMBL1147009 0.72 CDK1 (0.81) CDK1KDM4EHSD17B10LMNAHTT
SCHEMBL10888993 0.71 BCHE (0.53) CCR4CACNA2D1LMNASLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617619-B1 USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS UNIV ROCKEFELLER (US) 2003-09-10 EP claimed
EP-0617619-B1 USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS UNIV ROCKEFELLER (US) 2003-09-10 EP disclosed
EP-0617619-A1 USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS THE ROCKEFELLER UNIVERSITY (US) 1994-10-05 EP disclosed
US-5348963-A Method of screening for modulators of amyloid formation THE ROCKEFELLER UNIVERSITY (US) 1994-09-20 US disclosed
US-5242932-A TREATMENT OF AMYLOIDOSIS ASSOCIATED WITH ALZHEIMER DISEASE THE ROCKEFELLER UNIVERSITY (US) 1993-09-07 US disclosed
WO-1993011762-A1 USE OF APP MODULATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AMYLOIDOSIS THE ROCKEFELLER UNIVERSITY (US) 1993-06-24 WO disclosed