Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860052 | 0.85 | CES2 (0.65) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL4102909 | 0.84 | ALDH1A1 (0.62) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL13724641 | 0.81 | HDAC3 (0.50) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL9770790 | 0.79 | ALDH1A1 (0.46) | CES2CES1ALDH1A1CA2GSK3B | |
| SCHEMBL2842838 | 0.79 | CES2 (0.57) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL4098335 | 0.79 | ALDH1A1 (0.49) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL5685569 | 0.78 | ALDH1A1 (0.64) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL1115093 | 0.76 | CES2 (0.46) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL11266531 | 0.76 | CES2 (0.57) | CES2CES1ALDH1A1CYP1A2CA1 | |
| SCHEMBL2699118 | 0.76 | CES2 (0.46) | CES2CES1CYP1A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857475-A | Labelled and labellable reagents for fluorometric assays | Ekins, Roger Philip (GB) | 1989-08-15 | — | — | US | claimed |
| US-4565790-A | LANTHANIDE SERIES COMPLEX, B-DIKETONE, DETERGENT | WALLAC OY (FI) | 1986-01-21 | — | — | US | claimed |
| US-9017962-B2 | Intracellular reporters | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-04-28 | — | — | US | disclosed |
| EP-1943262-B1 | IRE-1 ALPHA SUBSTRATES | MANNKIND CORP (US) | 2013-01-23 | — | — | EP | disclosed |
| US-8252549-B2 | Multi-purpose substrates useful for cell culture and methods for making | CORNING INCORPORATED (US) | 2012-08-28 | — | — | US | disclosed |
| US-8236523-B2 | Camp reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-07 | — | — | US | disclosed |
| US-8124343-B2 | IRE-1α substrates | MANNKIND CORPORATION (US) | 2012-02-28 | — | — | US | disclosed |
| US-8080235-B2 | Protein kinase A reporters useful in high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-12-20 | — | — | US | disclosed |
| WO-2011149743-A1 | MULTIPLY FLUORESCENTLY LABELED CALCIUM PHOSPHATE-PROTEIN SURFACES | CORNING INCORPORATED (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110287952-A1 | IRE-1alpha SUBSTRATES | MANNKIND CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110275103-A1 | EMISSION RATIOMETRIC REPORTERS OF MEMBRANE PDK1 ACTIVATION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-10 | — | — | US | disclosed |
| US-20080096224-A1 | Emission ratiometric indicators of phosphoinositides | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-04-24 | — | — | US | disclosed |
| EP-1791972-A2 | cAMP REPORTERS | The Johns Hopkins University (US) | 2007-06-06 | — | — | EP | disclosed |
| US-20070111270-A1 | cAMP reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070105123-A1 | IRE-1alpha substrates | MANNKIND CORPORATION (US) | 2007-05-10 | — | — | US | disclosed |
| WO-2007053151-A1 | IRE-1α SUBSTRATES | MANNKIND CORPORATION (US) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007050734-A1 | PROTEIN KINASE A REPORTERS USEFUL IN HIGH THROUGHPUT ASSAYS | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2006023972-A2 | cAMP REPORTERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20050250171-A1 | Methods and tools for detecting collagen degradation | CAMBREX BIO SCIENCE WALKERSVILLE, INC. (US) | 2005-11-10 | — | — | US | disclosed |
| US-20010055776-A1 | High throughput cell-based assay kits | GREENWALT DALE (US) | 2001-12-27 | — | — | US | disclosed |