SCHEMBL9770790

SCHEMBL9770790

Cc1ccc(C(=O)C(F)C(=O)C(F)F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
CES2 O00748 3/20 0.46
CES1 P23141 3/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
PKM P14618 2/20 0.42
HTT P42858 2/20 0.42
ATM Q13315 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
HPGD P15428 1/20 0.42
NLRP1 Q9C000 1/20 0.42
GAA P10253 1/20 0.42
NTSR1 P30989 1/20 0.42
SRD5A2 P31213 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9732502 0.83 CES2 (0.61) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL711850 0.82 CES2 (0.48) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL1115093 0.80 CES2 (0.46) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL2699118 0.80 CES2 (0.46) CES2CES1LMNAMEN1KMT2A
SCHEMBL709890 0.79 CES2 (0.52) ALDH1A1CES2CES1LMNAMEN1
SCHEMBL9770879 0.79 ALDH1A1 (0.50) ALDH1A1LMNASMN1; SMN2HTTTDP1
SCHEMBL8220499 0.79 PLK1 (0.46) ALDH1A1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL523477 0.79 TDP1 (0.48) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL9565954 0.78 TDP1 (0.47) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL9770764 0.77 SMN1; SMN2 (0.47) ALDH1A1LMNASMN1; SMN2HTTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111423375-A Preparation method of COX-2 specific cyclooxygenase inhibitor 云南大学 2020-07-17 CN claimed
CN-116947618-B Novel beta-diketone compound and preparation method and application thereof 重庆康普化学工业股份有限公司 2025-03-11 CN disclosed
CN-116947618-A Novel beta-diketone compound and preparation method and application thereof 重庆康普化学工业股份有限公司 2023-10-27 CN disclosed
CN-111423375-A Preparation method of COX-2 specific cyclooxygenase inhibitor 云南大学 2020-07-17 CN disclosed
CN-111423375-A Preparation method of COX-2 specific cyclooxygenase inhibitor 云南大学 2020-07-17 CN disclosed
US-5006254-A Extraction with halogenated beta-diketone RHONE-POULENC CHIMIE (FR) 1991-04-09 US disclosed