Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358740 | 0.91 | RAB9A (0.42) | RAB9APAX8MEN1KMT2AMLNR | |
| SCHEMBL6916828 | 0.76 | SMN1; SMN2 (0.35) | PDE5A | |
| SCHEMBL6804504 | 0.74 | RAB9A (0.42) | RAB9APAX8MEN1KMT2AOPRD1 | |
| SCHEMBL3579719 | 0.73 | SMN1; SMN2 (0.38) | PDE5A | |
| SCHEMBL6356981 | 0.72 | PDE5A (0.38) | PDE5AMAPTALDH1A1 | |
| SCHEMBL70441 | 0.71 | CYP2D6 (0.46) | MEN1KMT2AADORA3SLC6A2SLC6A3 | |
| SCHEMBL13500478 | 0.69 | ALDH1A1 (0.35) | PDE5ALMNAMAPTALDH1A1 | |
| Maleic Acid SCHEMBL6971291 | 0.69 | ALDH1A1 (0.49) | MEN1KMT2ASCN9AOPRD1MGLL | |
| Fumaric Acid SCHEMBL6971299 | 0.69 | ALDH1A1 (0.49) | MEN1KMT2ASCN9AOPRD1MGLL | |
| SCHEMBL5514265 | 0.68 | CYP2D6 (0.41) | MEN1KMT2AADORA3SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368352-A1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002074774-A1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |