Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100163 | 0.83 | LTA4H (0.61) | LTA4HSMN1; SMN2DRD3DRD2 | |
| SCHEMBL7096353 | 0.82 | LTA4H (0.62) | LTA4HSMN1; SMN2DRD3DRD2TDP1 | |
| SCHEMBL28917645 | 0.78 | LTA4H (0.97) | LTA4HDRD3DRD2FLT3KDR | |
| SCHEMBL28917601 | 0.77 | LTA4H (1.00) | LTA4HDRD3DRD2FLT3KDR | |
| SCHEMBL17384760 | 0.76 | LTA4H (0.84) | LTA4HDRD3DRD2KDM4E | |
| SCHEMBL3925960 | 0.75 | LTA4H (0.52) | LTA4HSMN1; SMN2ESR1ESR2TSHR | |
| SCHEMBL18010724 | 0.72 | SMN1; SMN2 (0.74) | LTA4HSMN1; SMN2ESR1ESR2TSHR | |
| SCHEMBL4416535 | 0.72 | LTA4H (0.60) | LTA4HSMN1; SMN2ESR1ESR2TSHR | |
| SCHEMBL3442370 | 0.72 | LTA4H (0.60) | LTA4HSMN1; SMN2ESR1ESR2TSHR | |
| SCHEMBL227430 | 0.72 | LTA4H (0.60) | LTA4HSMN1; SMN2ESR1ESR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |