Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.37 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | INPP5B | P32019 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375671 | 0.83 | HDAC8 (0.43) | HDAC8ATMHDAC6HDAC2KDM4E | |
| SCHEMBL7099461 | 0.82 | TUBB1 (0.45) | HDAC8ATMHDAC6HDAC2KDM4E | |
| SCHEMBL6087582 | 0.71 | HDAC6 (0.38) | HDAC8HDAC6HDAC2HDAC11HDAC3 | |
| SCHEMBL7100377 | 0.66 | LMNA (0.50) | MAPTALDH1A1 | |
| SCHEMBL22909519 | 0.66 | TAS2R14 (0.48) | HDAC8HDAC6HDAC2ALDH1A1 | |
| SCHEMBL29671306 | 0.66 | TAS2R14 (0.48) | HDAC8HDAC6HDAC2ALDH1A1 | |
| SCHEMBL28762088 | 0.65 | HDAC8 (0.40) | HDAC8ATMHDAC6HDAC2MAPT | |
| SCHEMBL7534445 | 0.65 | TSHR (0.62) | ALDH1A1POLB | |
| SCHEMBL28412637 | 0.64 | INPPL1 (0.62) | INPPL1INPP5AKDM4EINPP5BALDH1A1 | |
| SCHEMBL27528600 | 0.63 | TUBB4A (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090014-B1 | ARYLSULFONANILIDE PHOSPHATES | TULARIK INC (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6417176-B2 | ANTICANCER AGENTS, PSORIASIS, RESTENOSIS, ATHEROSCLEROSIS | TULARIK, INC. | 2002-07-09 | — | — | US | disclosed |
| US-20010018430-A1 | Arylsulfonanilide phosphates | TULARIK, INC. | 2001-08-30 | — | — | US | disclosed |
| EP-1090014-A1 | ARYLSULFONANILIDE PHOSPHATES | Tularik Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6211167-B1 | ANTICHOLESTEROL, ANTIPROLIFERATIVE AND ANTILIPEMIC AGENTS; CANCER, PSORIASIS, ATHEROSCLEROSIS, INFECTION AND VASCULAR RESTENOSIS TREATMENT | TULARIK INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1999067258-A1 | ARYLSULFONANILIDE PHOSPHATES | TULARIK INC. (US) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018430-A1 | Arylsulfonanilide phosphates | PIK3CA, INPP5D, INPPL1 | HDAC8 1023/4885ATM 1222/4885HDAC6 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.