Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16124230 | 1.00 | LMNA (0.50) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL3237231 | 0.82 | ALDH1A1 (0.42) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL7101899 | 0.81 | AOC3 (0.39) | AOC3ALDH1A1MEN1KMT2A | |
| SCHEMBL14457821 | 0.81 | SLC6A2 (0.40) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL14457831 | 0.81 | SLC6A2 (0.40) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL23221180 | 0.75 | KDM4E (0.56) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL9201789 | 0.75 | KDM4E (0.56) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL3245155 | 0.75 | KDM4E (0.56) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL8287058 | 0.75 | KDM4E (0.56) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL10938300 | 0.75 | CYP2C19 (0.38) | LMNAAOC3ADRA2CKDM4EADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809647-B1 | CHIRAL ORGANOMETALLIC COMPOUNDS | AVECIA LTD (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-5929266-A | ZIRCONIUM, HAFNIUM, TITANIUM CYCLOPENTADIENE COMPOUNDS USEFUL IN ASYMMETRIC SYNTHESIS | ZENECA LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |