Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630392 | 0.93 | ESR2 (0.55) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL31264147 | 0.93 | ESR2 (0.55) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL14856915 | 0.93 | ESR2 (0.55) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL29294233 | 0.86 | CYP11B1 (0.40) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL31663517 | 0.85 | XDH (0.52) | CYP11B2ALDH1A1TDP1KDM4EGLA | |
| SCHEMBL21110859 | 0.83 | CYP2A6 (0.67) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL12853987 | 0.83 | CYP2A6 (0.67) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL31663540 | 0.83 | CNR1 (0.50) | CYP11B2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29487253 | 0.82 | CYP11B2 (0.58) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL19955349 | 0.82 | CYP11B2 (0.58) | CYP11B2ALDH1A1CYP1A2CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214319-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-11-26 | — | — | EP | disclosed |