Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ABCC9 | O60706 | 12/20 | 0.61 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.61 |
| ▸ | ABCC8 | Q09428 | 11/20 | 0.61 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833283 | 0.91 | GPR174 (0.76) | GPR174MEN1KMT2AL3MBTL1ABCC9 | |
| SCHEMBL7835762 | 0.83 | GPR174 (0.66) | GPR174MEN1KMT2AL3MBTL1ABCC9 | |
| SCHEMBL10818542 | 0.80 | KDM4E (0.50) | GPR174MEN1KMT2AL3MBTL1ABCC9 | |
| SCHEMBL22388477 | 0.79 | GPR174 (1.00) | GPR174MEN1KMT2AL3MBTL1GAA | |
| SCHEMBL7097711 | 0.79 | ABCC9 (0.82) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7101209 | 0.78 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7099014 | 0.78 | ABCC9 (0.66) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7095119 | 0.78 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7100235 | 0.78 | ABCC9 (0.67) | GPR174ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL3325408 | 0.77 | KDM4E (0.65) | GPR174MEN1KMT2AL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |