Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104436 | 0.82 | AR (0.35) | — | |
| SCHEMBL7102507 | 0.81 | — | — | |
| SCHEMBL7097335 | 0.81 | NR1H2 (0.37) | NR1H2NR1H3 | |
| SCHEMBL7102225 | 0.81 | — | — | |
| SCHEMBL7100147 | 0.78 | HSD11B1 (0.34) | — | |
| SCHEMBL6444368 | 0.78 | ACACB (0.37) | NR1H2NR1H3 | |
| SCHEMBL28749688 | 0.77 | AOC3 (0.39) | NR1H2NR1H3 | |
| SCHEMBL1626543 | 0.77 | NOTUM (0.38) | CCNT1CDK9 | |
| SCHEMBL1626163 | 0.77 | CXCR3 (0.32) | CCNT1CDK9 | |
| SCHEMBL7101227 | 0.77 | NOTUM (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |