Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 16/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097335 | 0.81 | NR1H2 (0.37) | NR1H2NR1H3 | |
| SCHEMBL7101227 | 0.79 | NOTUM (0.31) | — | |
| SCHEMBL7101205 | 0.78 | TDP1 (0.31) | NR1H2NR1H3 | |
| SCHEMBL7104436 | 0.75 | AR (0.35) | IRAK4 | |
| SCHEMBL7102507 | 0.74 | — | — | |
| SCHEMBL7102225 | 0.74 | — | — | |
| SCHEMBL6425191 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL7100147 | 0.71 | HSD11B1 (0.34) | — | |
| SCHEMBL28749688 | 0.70 | AOC3 (0.39) | NR1H2NR1H3 | |
| SCHEMBL6017895 | 0.69 | DHFR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |