Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 2/20 | 0.52 |
| ▸ | STS | P08842 | 7/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571107 | 0.82 | SHBG (0.60) | SHBGSTSHSD17B1CYP19A1ESR1 | |
| SCHEMBL3370529 | 0.80 | STS (0.50) | SHBGSTSHSD17B1CYP19A1ABCC4 | |
| SCHEMBL6869789 | 0.79 | STS (0.64) | SHBGSTSCA2CA9 | |
| SCHEMBL8088835 | 0.78 | SHBG (0.54) | SHBGSTSHSD17B1CYP19A1ESR1 | |
| SCHEMBL3374308 | 0.78 | STS (0.52) | SHBGSTSHSD17B1ABCC4ESR1 | |
| SCHEMBL8216010 | 0.78 | STS (0.52) | SHBGSTSHSD17B1ABCC4ESR1 | |
| SCHEMBL3381342 | 0.77 | SHBG (0.67) | SHBGSTSHSD17B1CYP19A1ABCC4 | |
| SCHEMBL1259385 | 0.77 | SHBG (0.67) | SHBGSTSHSD17B1CYP19A1ABCC4 | |
| SCHEMBL3373874 | 0.75 | STS (0.48) | SHBGSTSHSD17B1ABCC4ESR1 | |
| SCHEMBL9194502 | 0.75 | SHBG (0.60) | SHBGSTSHSD17B1CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775156-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRA-1,3,5(10)-TRIENE DERIVATIVES | JENAPHARM GMBH (DE) | 2003-09-03 | — | — | EP | claimed |