SCHEMBL8088835

SCHEMBL8088835

C[C@@]12CCC[C@H]1[C@@H]1CCc3cc(O)c(C=O)c(O)c3[C@H]1CC2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.54
STS P08842 4/20 0.49
CYP19A1 P11511 7/20 0.43
ESR1 P03372 4/20 0.43
ESR2 Q92731 2/20 0.43
HSD17B1 P14061 9/20 0.41
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
G6PD P11413 1/20 0.38
PKM P14618 1/20 0.38
MAPK1 P28482 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
DAB2IP Q5VWQ8 1/20 0.38
ADCY10 Q96PN6 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8571107 0.86 SHBG (0.60) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL8409463 0.82 SHBG (0.45) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL6869789 0.79 STS (0.64) SHBGSTS
SCHEMBL9194502 0.79 SHBG (0.60) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL3972911 0.79 CYP19A1 (0.69) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL7101544 0.78 SHBG (0.52) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL3968674 0.76 SHBG (0.55) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL5143409 0.76 SHBG (0.74) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL7163758 0.75 SHBG (0.66) SHBGSTSCYP19A1ESR1ESR2
SCHEMBL3370529 0.75 STS (0.50) SHBGSTSCYP19A1ESR1HSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042354-A2 ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE SRI INTERNATIONAL (US) 2000-10-11 EP disclosed
WO-1999033858-A2 ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE SRI INTERNATIONAL (US) 1999-07-08 WO disclosed