SCHEMBL7101916

SCHEMBL7101916

CNN1CCC[C@@H](c2cncc(OC)c2)C1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.41
GCK P35557 1/20 0.40
PROKR1 Q8TCW9 3/20 0.39
CHRNB2 P17787 7/20 0.38
CHRNA4 P43681 6/20 0.38
CHRNB4 P30926 5/20 0.38
CHRNA3 P32297 5/20 0.38
CHRNB1 P11230 1/20 0.37
CHRNB3 Q05901 1/20 0.37
IDO1 P14902 1/20 0.36
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7102433 1.00 DRD2 (0.41) DRD2GCKPROKR1CHRNB2CHRNA4
SCHEMBL7097805 0.96 PROKR1 (0.41) DRD2GCKPROKR1CHRNB2CHRNA4
SCHEMBL7102531 0.96 PROKR1 (0.41) DRD2GCKPROKR1CHRNB2CHRNA4
SCHEMBL7487273 0.92 CHRNB2 (0.39) GCKCHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7097543 0.92 CHRNB2 (0.39) GCKCHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7102502 0.90 IDO1 (0.39) DRD2GCKCHRNB2CHRNA4CHRNB4
SCHEMBL7102471 0.90 IDO1 (0.39) DRD2GCKCHRNB2CHRNA4CHRNB4
SCHEMBL7102968 0.81 JAK2 (0.37)
SCHEMBL7098415 0.81 JAK2 (0.37)
SCHEMBL7102428 0.81 CHRNA3 (0.55) DRD2CHRNB2CHRNA4CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed