Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 7/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553664 | 0.81 | KDM4E (0.49) | TAS2R14AKR1C3AKR1C2RXRANR1H2 | |
| SCHEMBL15920582 | 0.73 | KDM4E (0.54) | RXRANR1H2NR1H3RXRBKDM4E | |
| SCHEMBL29756075 | 0.73 | KDM4E (0.54) | RXRANR1H2NR1H3RXRBKDM4E | |
| SCHEMBL4417351 | 0.73 | KDM4E (0.54) | RXRANR1H2NR1H3KDM4EUSP2 | |
| SCHEMBL8570209 | 0.72 | RXRA (0.41) | RXRANR1H2NR1H3RXRBKDM4E | |
| SCHEMBL28740934 | 0.71 | CFTR (0.57) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL3886144 | 0.70 | LIPC (0.58) | TAS2R14AKR1C3AKR1C2KDM4EUSP2 | |
| SCHEMBL22525059 | 0.70 | TAS2R14 (0.58) | TAS2R14AKR1C3AKR1C2KDM4EUSP2 | |
| SCHEMBL686427 | 0.69 | RXFP1 (0.58) | TAS2R14AKR1C3AKR1C2KDM4EUSP2 | |
| SCHEMBL1452551 | 0.69 | GRIK1 (0.55) | TAS2R14AKR1C3AKR1C2KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343751-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002060859-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |