SCHEMBL7102141

SCHEMBL7102141

COc1cccc(C=CC(=O)c2ccc(N)cc2)c1OC

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.76
MAOB P27338 3/20 0.73
ABCG2 Q9UNQ0 1/20 0.66
NFE2L2 Q16236 2/20 0.65
CA1 P00915 1/20 0.64
CA2 P00918 1/20 0.64
KRAS P01116 1/20 0.64
RELA Q04206 3/20 0.64
NPC1 O15118 2/20 0.63
RAB9A P51151 2/20 0.63
CYP19A1 P11511 1/20 0.62
CTSL P07711 1/20 0.61
CTSB P07858 1/20 0.61
CYP1A1 P04798 1/20 0.61
CYP1A2 P05177 1/20 0.61
CYP2D6 P10635 1/20 0.61
LMNA P02545 2/20 0.60
ALDH1A1 P00352 1/20 0.60
NTSR1 P30989 1/20 0.60
TDP1 Q9NUW8 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6357636 0.88 ALOX5 (0.78) ALOX5MAOBABCG2NFE2L2RELA
SCHEMBL31676388 0.88 ALOX5 (0.78) ALOX5MAOBABCG2NFE2L2KRAS
SCHEMBL7099857 0.88 ABCG2 (0.86) ALOX5MAOBABCG2CA1CA2
SCHEMBL6357635 0.88 ALOX5 (0.78) ALOX5MAOBABCG2NFE2L2RELA
SCHEMBL4026900 0.87 LMNA (0.78) ALOX5MAOBABCG2NFE2L2RELA
SCHEMBL7099853 0.87 MAPT (0.78) MAOBABCG2NFE2L2CA1CA2
SCHEMBL7100872 0.87 MAOB (0.69) ALOX5MAOBABCG2NFE2L2RELA
SCHEMBL11296305 0.84 ALOX5 (0.73) ALOX5MAOBABCG2NFE2L2RELA
SCHEMBL7097737 0.84 ALOX5 (0.73) ALOX5MAOBABCG2NFE2L2KRAS
SCHEMBL7097251 0.84 ALOX5 (0.73) ALOX5MAOBABCG2NFE2L2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO claimed
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO disclosed