SCHEMBL7102423

SCHEMBL7102423

Cc1cc(NN2CCCC2)cnc1Cl

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 9/20 0.38
CHRNA4 P43681 9/20 0.38
CHRNB4 P30926 8/20 0.38
CHRNA3 P32297 8/20 0.38
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
DHODH Q02127 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7098002 0.98 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3DHODH
Hydrochloric Acid SCHEMBL7487751 0.98 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3HTT
SCHEMBL7100981 0.98 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3DHODH
Hydrochloric Acid SCHEMBL7486498 0.98 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3HTT
SCHEMBL7103269 0.83 ALDH1A1 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3L3MBTL1
SCHEMBL7101903 0.81 METAP2 (0.32)
SCHEMBL7097832 0.81 ALDH1A1 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3L3MBTL1
SCHEMBL7099158 0.81 ALDH1A1 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3L3MBTL1
Hydrochloric Acid SCHEMBL7487748 0.81 ALDH1A1 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3L3MBTL1
SCHEMBL7097813 0.80 MAPT (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed