Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502103 | 0.93 | NPC1 (0.66) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL4392160 | 0.91 | NPC1 (0.53) | NPC1CYP2C8MAPTHTTSMN1; SMN2 | |
| SCHEMBL8339910 | 0.91 | NPC1 (0.50) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL8458977 | 0.87 | NPC1 (0.59) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL8458703 | 0.87 | NPC1 (0.59) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL7101319 | 0.86 | MAPT (0.64) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL8460805 | 0.86 | BACE1 (0.57) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL8460808 | 0.85 | ALDH1A1 (0.57) | NPC1CYP2C8MAPTHTTNPSR1 | |
| SCHEMBL6778891 | 0.84 | SMN1; SMN2 (0.62) | NPC1CYP2C8MAPTSMN1; SMN2RAB9A | |
| SCHEMBL8716568 | 0.83 | NPC1 (0.55) | NPC1CYP2C8MAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838464-B1 | Substituted benzo(b)thiophene compounds having activity as selective estrogen receptor modulators | LILLY CO ELI (US) | 2003-09-10 | — | — | EP | claimed |
| EP-0838464-A1 | Substituted benzo(b)thiophene compounds having activity as selective estrogen receptor modulators | ELI LILLY AND COMPANY (US) | 1998-04-29 | — | — | EP | disclosed |